Staff
Head of the Laboratory — Vadim V. Shmanai, Ph.D.
Address: office №313, 13 Surganov street, Minsk 220072, Belarus
Phone / Fax: +375 17 284-20-55
E-mail: shmanai
ifoch.bas-net.by
H-index: 7; citations: 72
EDUCATION
SCIENTIFIC BACKGROUND
RESEARCH INTERESTS
MAIN PUBLICATIONS
EDUCATION
1989 M.Sc. (Chemistry) Belarusian State University, Minsk, Belarus.
2000 Ph.D. “Functionalization of polymer carrier supports for immunochemical analysis” (Chemistry of Macro-Molecular Compounds) Institute of Physical Organic Chemistry, Minsk, Belarus.
SCIENTIFIC BACKGROUND
2003 – 2010 Senior Research Scientist. Department of Macro-Molecular Compounds. Interests: bioconjugation; chemistry of fluorescent dyes; synthesis of labeled biomolecules; modification of biomolecules with functional or anchor groups for conjugation and immobilization; modified oligonucleotides; conjugation of biomolecules with affinity ligands; PEGylation of biomolecules; surface modification and immobilization of biomolecules on hydrogels, molded polymers, synthetic membranes; bio-affinity polymer materials and surfaces for affinity chromatography, (Affinity) LDI TOF MS.
2001 – 2002 Senior Research Scientist. Department of Medicinal Substances: development, synthesis and analysis of medicinal substances.
RESEARCH INTERESTS
Chemistry: methods of bioconjugation; functional linkers for bioconjugation, PEGylation of biomolecules; treblers, dendrimers; functional derivatives of fluorescent dyes; mass-tags for bioanalytics; functionalization of surfaces for mass spectrometry, affinity chromatography and immunoassays; custom synthesis of biologically active molecules.
Bioorganic chemistry: modified oligonucleotides; fluorescent and affinity labeled DNA; immunoassay; immuno-PCR; immobilized antibodies and affinity ligands for chromatography, affinity MALDI-TOF MS and SPR; protein-protein interactions; post-translation modifications; search of bio-markers.
MAIN PUBLICATIONS
1. Pestov N., Okkelman I., Shmanai V., Hurski A., Giaccia A., Shchepinov M. "Control of lysyl oxidase activity through site-specific deuteration of lysine". Bioorganic & Medicinal Chemistry Letters 2011, 21, 255–258. (Abstract)
2. Hill S., Hirano K., Shmanai V., Marbois B., Vidovic D., Bekish A., Kay B., Tse V., Fine J., Clarke C., Shchepinov M. "Isotope-Reinforced Polyunsaturated Fatty Acids Protect Yeast Cells from Oxidative Stress". Free Radical Biology and Medicine 2011, 50, 130–138. (Abstract, Free in PubMed Central)
3. Kvach M., Stepanova I., Prokhorenko I., Stupak A., Bolibrukh D., Korshun V., and Shmanai V. "Practical Synthesis of Isomerically Pure 5- and 6-Carboxytetramethylrhodamines, Useful Dyes for DNA Probes". Bioconjugate Chemistry 2009, 20, 1673–1682. (Abstract)
4. Ustinov A. V., Shmanai V. V., Patel K., Stepanova I. A., Prokhorenko I. A., Astakhova I. V., Malakhov A. D., Skorobogatyi M. V., Bernad P. L., Jr, Khan S., Shahgholi M., Southern E. M., Korshun V. A., and Shchepinov M. S. "Reactive Trityl Derivatives: Stabilized Carbocation Mass-tags for Life Sciences Applications". Organic & Biomolecular Chemistry 2008, 6, 4593–4608. (Full Text)
5. Birikh K. R., Bernad P. L., Shmanai V. V., Malakhov A. D., Shchepinov M. S. and Korshun V. A. "SNP Detection Using Trityl Mass-Tags". Methods in Molecular Biology (Clifton, N.J.) 2009, 578, 345–361. (Abstract)
6. Kvach M. V., Skorobogatyi M. V., Malakhov A. D., Ustinov A. V., Stepanova I. A., Shmanai V. V., Korshun V. A. "Convenient synthesis of cyanine dyes: reagents for labeling of biomolecules". European Journal of Organic Chemistry 2008, 12, 2107–2117. (Abstract)
7. Shmanai V., Gontarev S., Frey S., Schweigert F. "Modification of aluminum chips for LDI mass spectrometry of proteins". Journal of Mass Spectrometry 2007, 42(11), 1504–1513. (Abstract)
8. Kvach M. V., Tsybulsky D. A., Ustinov A. V., Stepanova I. A., Bondarev S. L., Gontarev S. V., Korshun V. A., Shmanai V. V. "5(6)-Carboxyfluorescein revisited: new protecting group, separation of isomers, and their spectral properties on oligonucleotides". Bioconjugate Chemistry 2007, 18(5), 1691–1696. (Abstract)
9. Gontarev S., Shmanai V., Frey S., Kvach M., Schweigert F. "Application of phenylboronic acid modified hydrogel affinity chips for high-throughput mass spectrometric analysis of glycated proteins". Rapid Communications in Mass Spectrometry 2007, 21, 1–6. (Abstract)
10. Kvach M., Prokhorenko I., Ustinov A., Gontarev S., Korshun V., Shmanai V. "Reagents for the selective immobilization of oligonucleotides on solid supports". Nucleosides, Nucleotides and Nucleic Acids 2007, 26 (6), 809–813. (Abstract)
11. Skorobogatyi M., Kvach M., Zhylinskaya M., Yarmolinsky D., Korshun V., Shmanai V. "5-Arylethynyl-2′-deoxyuridines: energy transfer and SNP detection". Nucleosides, Nucleotides and Nucleic Acids 2007, 26 (6), 767–772. (Abstract)
12. Kvach M., Prokhorenko I., Ustinov A., Gontarev S., Korshun V., Shmanai V. "Reagents for the selective conjugation of oligonucleotides". International Roundtable on Nucleosides, Nucleotides and Nucleic Acids 2006, 137.
13. Skorobogatyi M., Kvach M., Zhylinskaya M., Yarmolinsky D., Korshun V., Shmanai V.. "Through-stack energy transfer for SNP detection". International Roundtable on Nucleosides, Nucleotides and Nucleic Acids 2006, 121.
14. Kvach M. V., Gontarev S. V., Prokhorenko I. A., Stepanova I. A., Shmanai V. V., Korshun V. A. "Simple reagent for the synthesis of oligonucleotides labeled with 3,3,3’,3’-tetramethyl-2,2'-indodicarbocyanine". Russian Chemical Bulletin, International Edition 2006, 55 (1), 159–163.
15. Shmanai V. V., Litoshka A. A. "Solid-phase macrosupports for immunoassay modified with polysaccharides". Russian Journal of Applied Chemistry 2001, 74 (8), 1312–1316.
16. Shmanai V. V., Nikolayeva T. A., Vinokurova L. G., Litoshka A. A. "Oriented antibody immobilization to polystyrene macrocarriers for immunoassay modified with hydrazide derivatives of poly(meth)acrylic acid". BMC Biotechnology 2001, 1, 4. (Abstract)
17. Vinokurova L. G., Shmanai V. V. "Sulfonation of formylated polystyrene carriers for solid-phase immunoassay". Vestzi Akad. Navuk Belarusi. Ser. Khim. Navuk 2001, 2. — In Russian.
18. Shmanai V. V., Vinokurova L. G., Nikolaeva T. A. "New polymer matrices with improved properties for solid-phase immunoassay". Doklady NAN Belarusi 2001, 45 (2), 67–70. — In Russian.
19. Shmanai V. V., Vinokurova L. G., Soldatenko J. I. "The uniformity of immunosorbents based on formylated polystyrene beads". Biotekhnologya 2000, 5, 61–65. — In Russian.
20. Shmanai V. V., Markovich M. M., Naidenov V. E., Vinokurova L. G., Soldatenko J. I., Bandarik S. J., Nikolaeva T. A. "Immunosorbents based on formylated polystyrene beads". Biotekhnologya 2000, 5, 55–60. — In Russian.
21. Shmanai V. V. "Immobilization of proteins on formylated polystyrene supports for immunochemical analysis". Doklady NAN Belarusi 2000, 44 (1), 61–64. — In Russian.
22. Shmanai V. V. "ELISA of hCG using formylated polystyrene spheres as the carrier". Vestzi Akad. Navuk Belarusi. Ser. Khim. Navuk 2000, 1, 89–93. — In Russian.
23. Shmanai V. V., Bylina G. S. "Proteins immobilization on formylated polystyrene supports". Reactive and Functional Polymers 2000, 43 (3), 243–251.
24. Shmanai V. V., Naidenov V. E. "Rapid determination of human immunoglobulin G by ELISA". Russian Journal of Analytical Chemistry 1999, 54 (6), 581–586.
25. Shmanai V. "Blocking of non-specific sorption in ELISA on formylated polystyrene beads". Journal of Immunoassay 1999, 20 (1–2), 13–30. (Abstract)
26. Shmanai V. V., Vinokurova L. G. "Stabilization of surface layer of formylated polystyrene carriers used in immunoanalysis for their desiccation". Biotekhnologya 1999, 2, 65–68. — In Russian.
27. Shmanai V. V., Nikolaeva T. A., Vinokurova L. G. "Synthesis of spacer hydrazide groups on moulded carriers for solid-phase immunoassay". Biotekhnologya 1999, 2, 59–64. — In Russian.
28. Shmanai V. V. Bylina G. S. "Reactions of proteins with formylated polystyrene beads". Russian Journal of Applied Chemistry 1998, 71 (4), 686–691.
29. Bylina G. S., Vinokurova L. G., Shmanai V. V. "Reaction of formylated polystyrene beads used in immunoassay with primary amines". Russian Journal of Applied Chemistry 1998, 71 (4), 682–685.
30. Bylina G. S., Vinokurova L. G., Shmanai V. V. "Structure of the surface layer of formylated polystyrene spheres used as solid-phase matrices for chemical immunoassay". Russian Journal of Applied Chemistry 1996, 69 (3), 443–446.
31. Shmanai V. V., Bylina G. S., Vinokurova L. G. "Quantitative determination of carbonyl groups on a surface of modified polystyrene matrices for immunological analysis". Vestzi Akad. Navuk Belarusi. Ser. Khim. Navuk 1995, 1, 9–13. — In Russian.
32. Eremin A. N., Bylina G. S., Shmanai V. V., Metelitza D. I. "Enzyme microimmunoassay of hydrocortisone and progesterone with usage of a paper modified with polymers". Zhurnal Analiticheskoj Khimii 1993, 48 (1), 137–144. — In Russian.
33. Shmanai V. V., Bylina G. S., Eremin A. N., Metelitza D. I. "Bioaffinity sorbents based on a paper modified with polymers". Vestzi Akad. Navuk Belarusi. Ser. Khim. Navuk 1992, 5–6, 50–56. — In Russian.
Senior Research Scientist — Maksim V. Kvach, Ph.D.
Address: office №311, 13 Surganov street, Minsk 220072, Belarus
Phone / Fax: +375 17 284-20-55
E-mail: m.kvachgmail.com
EDUCATION
RESEARCH INTERESTS
MAIN PUBLICATIONS
EDUCATION
2013, April – present time: Senior researcher in the Laboratory of Bioconjugate Chemistry, Institute of Physical Organic Chemistry of the NASB.
2010, February – 2013, March: Research Associate in the Laboratory of Bioconjugate Chemistry headed by Dr. Vadim V. Shmanai, Institute of Physical Organic Chemistry of the National Academy of Science of Belarus.
2010, February, 9: The defense of Ph.D. thesis.
2004, September – 2010, February: Ph.D. Student in the Laboratory of Boconjugate Chemistry headed by Dr. Vadim V. Shmanai, Institute of Physical Organic Chemistry NASB. Ph.D. thesis: “Synthesis of xanthene and indocyanine dyes and obtaining of fluorescently labeled oligonucleotides on their basis”.
• 2008, June – 2008, December: trainee in the laboratory of Nucleic Acids headed by Dr. Vladimir A. Korshun, Institute of Bioorganic Chemistry of the Russian Academy of Science. Collaborative project “Synthesis of Oligonucleotide Conjugates by the [3+2]-Cycloaddition Reaction”.
• 2006, February – 2007, August: trainee in the BioAnalyt GmbH headed by Prof. F.J. Schweigert, Potsdam, Germany. Collaborative project “Surface Modification for Antibodies Fixation and Selective Obtaining of Posttranslational Modifications, and for Protein-Protein Interactions of Diagnostic Important Markers”.
1999, September – 2004, June: Student, Belorussian State University, Department of Chemistry. Specialization: organic chemistry. The title of Diploma thesis is “A New Method of Preparation of 2-Substituted 1,3-Butadienes”.
1988, September – 1999, June: Gymnasium of Soligorsk (BELARUS). Profile subjects: chemistry, physics, math and biology.
RESEARCH INTERESTS
Organic synthesis of fluorescent and non-fluorescent dyes for the labeling of biomolecules (oligonucleotides, peptides, proteins). Development of synthesis and modification of oligonucleotides. Investigation of photophysical properties of fluorescent dyes conjugated with biomolecules.
MAIN PUBLICATIONS
1. Kvach M. V., Tsybulsky D. A., Shmanai V. V., Prokhorenko I. A., Stepanova I. A., Korshun V. A. "Non-nucleoside phosphoramidites of xanthene dyes (FAM, JOE, and TAMRA) for oligonucleotide labeling". Current Protocols in Nucleic Acid Chemistry 2013, Suppl. 52, 4.55.1–4.55.33. (Abstract)
2. Ryazantsev D. Y., Tsybulsky D. A., Prokhorenko I. A., Kvach M. V., Martynenko Y. V., Philipchenko P. M., Shmanai V. V., Korshun V. A., Zavriev S. K. "Two-dye and one- or two-quencher DNA probes for real-time PCR assay: synthesis and comparison with a TaqMan™ probe". Analytical and Bioanalytical Chemistry 2012, 404, 59–68. (Abstract)
3. Tsybulsky D. A., Kvach M. V., Stepanova I. A., Korshun V. A., Shmanai V. V. "4′,5′-Dichloro-2′,7′-dimethoxy-5(6)-carboxyfluorescein (JOE): synthesis and spectral properties of oligonucleotide conjugates". The Journal of Organic Chemistry 2012, 77, 977–984. (Abstract)
4. Kvach M. V., Stepanova I. A., Prokhorenko I. A., Stupak A. P., Bolibrukh D. A., Korshun V. A., Shmanai V. V. "Practical synthesis of isomerically pure 5- and 6-carboxytetramethylrhodamines, useful dyes for DNA probes". Bioconjugate Chemistry 2009, 20, 1673–1682. (Abstract)
5. Kvach M. V., Ustinov A. V., Stepanova I. A., Malakhov A. D., Skorobogatyi M. V., Shmanai V. V., Korshun V. A. "A Convenient Synthesis of Cyanine Dyes: Reagents for the Labeling of Biomolecules". European Journal of Organic Chemistry 2008, 2107–2117. (Abstract)
6. Gontarev S., Shmanai V., Frei S. K., Kvach M., Schweigert F. J. "Application of phenylboronic acid modified hydrogel affinity chips for high-throughput mass spectrometric analysis of glycated proteins". Rapid Communications in Mass Spectrometry 2007, 21, 1–6. (Abstract)
7. Kvach M. V., Tsybulsky D. A., Ustinov A. V., Stepanova I. A., Bondarev S. L., Gontarev S. V., Korshun V. A., Shmanai V. V. "5(6)-Carboxyfluorescein revisited: new protecting group, separation of isomers, and their spectral properties on oligonucleotides". Bioconjugate Chemistry 2007, 18, 1691–1696. (Abstract)
8. Skorobogatyi M. V., Kvach M. V., Zhylinskaya M. A., Yarmolinsky D. G., Korshun V. A., Shmanai V. V. "5-Aryletynyl-2′-deoxyuridines: energy transfer and SNP-detection". Nucleosides, Nucleotides and Nucleic Acids 2007, 26, 767–772. (Abstract)
9. Kvach M. V., Prokhorenko I. A., Ustinov A. V., Gontarev S. V., Korshun V. A., Shmanai V. V. "Reagents for the selective immobilization of oligonucleotides on solid supports". Nucleosides, Nucleotides and Nucleic Acids 2007, 26, 809–813. (Abstract)
10. Kvach M. V., Gontarev S. V., Prokhorenko I. A., Stepanova I. A., Shmanai V. V., and Korshun V. A. "Simple reagent for the synthesis of oligonucleotides labeled with 3,3,3’,3’-tetramethyl-2,2’-indodcarbocyanine". Russian Chemical Bulletin, International Edition 2006, 55, 159–163. (Abstract)
Senior Research Scientist — Olga L. Sharko, Ph.D.
Address: office №207, 13 Surganov street, Minsk 220072, Belarus
Phone / Fax: +375 17 284-20-55
E-mail: sharkoifoch.bas-net.by
EDUCATION
RESEARCH INTERESTS
MAIN PUBLICATIONS
EDUCATION
2000 – 2005 Student, Belarusian State University, Department of Chemistry. Specialization: organic chemistry.
2005 – 2006 Junior Research Scientist in the Laboratory of Lipid Chemistry, Institute of Bioorganic Chemistry of the National Academy of Science of Belarus.
2006 – 2009 PhD Student in the Laboratory of Lipid Chemistry, Institute of Bioorganic Chemistry of the National Academy of Science of Belarus.
2010, May, 25 Defence of PhD thesis, specialization: bioorganic chemistry (“Modulation of lipid hydrolases by fatty acid amides”, supervisor Prof. Dr. M. A. Kisel)
RESEARCH INTERESTS
Synthesis of phospholipids and fatty acid derivatives, synthesis of labeled phospholipids for phospholipase assaying.
MAIN PUBLICATIONS
1. Bezuglov V. V., Gretskaya N. M., Blazhenova A. V., Andrianova E. L., Akimov M. G., Bobrov M. Yu., Nazimov I. V., Kisel’ M. A., Sharko O. L., Novikov A. V., Krasnov N. V., Shevchenko V. P., Shevchenko K. V., V’yunova T. V., Myasoedov N. F. "Arachidonoyl amino acids and arachidonoyl peptides: synthesis and properties". Russian Journal of Bioorganic Chemistry 2006, 32 (3), 231–239. (Abstract)
2. Sharko O. L., Blazhenova A. V. "Modulation of phospholipases A2 type I and fatty acid amide hydrolase activities by arachidonoylaminoacids and arachidonoylaminoalcoholes". Proceedings of the National Academy of Sciences of Belarus, Series of Chemical Sciences 2006, 5, 103–105. — In Russian.
3. Sharko O. L., Kniazeva O. V. "Synthesis of 1-O-alkyl-2-[N-(2,4-dinitrophenyl)-β-aminopropionyl]-sn-glycero-3-phosphocholine — chromogenic analogue of platelet activating factor". Vestnik of the Foundation for Fundamental Research 2009, 3, 5–10. — In Russian.
4. Sharko O. L., Kisel M. A. "1-Acyl-2-[N-(2,4-dinitrophenyl)aminopropionyl]-sn-glycero-3-phosphocholine as a chromogenic substrate for phospholipase A2 assay". Anal. Biochem. 2011, 413 (1), 69–71. (Abstract)
Research Scientist — Ivan L. Lysenko, Ph.D.
Address: office №312, 13 Surganov street, Minsk 220072, Belarus
Phone / Fax: +375 17 284-20-55 Cell: + 375 25 6183717
E-mail: lysenkoigmail.com
EDUCATION
RESEARCH INTERESTS
MAIN PUBLICATIONS
EDUCATION
Ph.D. in Organic Chemistry (2004)
Belarusian State University, Minsk, Belarus.
Research advisor: Prof. O. G. Kulinkovich
Thesis: “Reaction of α-amino esters with titanacyclopropane reagents. Chemical properties of 1-(1-aminoalkyl)cyclopropanols”
Research Areas:
• Adaptation of the Kulinkovich reaction for cyclopropanation of α-amino esters;
• Regioselective ring opening of 1-(1-aminoalkyl)-cyclopropanols for preparation of nitrogen containing heterocyclic compounds;
• Synthesis of natural products bearing cyclopropanols;
B.S. in Chemistry (1997)
Belarusian State University, Minsk, Belarus.
Major: Organic Chemistry
Supervisor: Prof. O. G. Kulinkovich
Thesis: “Cyclopropanation of α-hydroxy esters”.
RESEARCH INTERESTS
• Design and synthesis of new fluorescent dyes for modification of biomolecules;
• Synthesis and purification of the deuterated unsaturated fatty acids
MAIN PUBLICATIONS
1. Lysenko I. L., Kulinkovich O. G. A convenient procedure for preparation of 1-(1-amino-alkyl)-1-cyclopropanols from N-benzyl α-amino esters. Russian Journal of Organic Chemistry 2001, 37 (9), 1238–1243.
2. Lysenko I. L., Bekish A. V., Kulinkovich O. G. Stereoselective Conversion of Ethyl Pipecolinate into (±)-α- and (±)-β-Conhydrins. Russian Journal of Organic Chemistry 2002, 38 (6), 875–879. (Abstract)
3. Lysenko I. L., Kulinkovich O. G. Stereoselective synthesis of (7aS)-1-methylenehexahydro-1H-pyrrolizine and (–)-heliotridane from N-diphenylmethyl-(S)-proline ethyl ester. Russian Journal of Organic Chemistry 2005, 41 (1), 70–74. (Abstract)
4. Kulinkovich O. G., Kozyrkov Y. Y., Bekish A. V., Matiushenkov E. A., Lysenko I. L. A convenient way for the conversion of carboxylic esters into 2-substituted allyl halides. Synthesis 2005, 10, 1713–1717. (Abstract)
5. Lysenko I. L., Lee H. G., Cha J. K. Use of cyclopropanols as conformational constraints in RCM. Organic Letters 2006, 8 (13), 2671–2673. (Abstract)
6. Lee H. G., Lysenko I. L., Cha J. K. Stereoselective synthesis of 2,4,6-trisubstituted tetrahydropyrans by use of cyclopropanols as homoenols. Angewandte Chemie International Edition 2007, 46 (18), 3326–3328. (Abstract)
7. Lysenko I. L., Oh H.-S., Cha J. K. Diastereoselective Prins-Type Reaction of Cycloalkenylcyclopropanol Silyl Ethers and α,β-Unsaturated Aldehyde Acetals. The Journal of Organic Chemistry 2007, 72 (21), 7903–7908. (Abstract)
8. Lee H. G., Lysenko I. L., Cha J. K. Enantioselective preparation of (+)- and (–)-Z-2-hydroxyethyl-1-methylcyclopropan-1-ol. ARKIVOC 2008, (ix), 133–139. (Abstract)
9. Lysenko I. L., Kim K., Lee H. G., Cha J. K. Low-valent titanium-mediated stereoselective alkylation of allylic alcohols. Journal of the American Chemical Society 2008, 130 (47), 15997–16002. (Abstract)
10. Lysenko I. L., Lee H. G., Cha J. K. Stereoselective Cross-Coupling between Allylic Alcohols and Aldimines. Organic Letters 2009, 11 (14), 3132–3134. (Abstract)
11. Das P. P., Lysenko I. L., Cha J. K. Stereoselective Alkylation of Allylic Alcohols by Tandem Ethylation and Functionalization. Angewandte Chemie International Edition 2011, 50 (40), 9459–9461. (Abstract)
Research Scientist — Aleksey P. Kadutskiy
Address: office №227, 13 Surganov street, Minsk 220072, Belarus
Phone / Fax: +375 17 284-20-55
E-mail: kadutskiytut.by
EDUCATION
RESEARCH INTERESTS
MAIN PUBLICATIONS
EDUCATION
11.1998 – 11.2001 — Full-time postgraduate course at Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus,
Minsk, Belarus
09.1991 – 06.1996 — Belarusian State University, University Diploma in Chemistry, Minsk, Belarus
09.1981 – 06.1991 — Maths school №10, Secondary School Certificate,
Minsk, Belarus
RESEARCH INTERESTS
Chemistry of heterocyclic compounds (piperidines, quinolines, acridines, fluoranes), Multicomponent reaction, β-diketones, anilines, Mannich reaction, azaspiro compounds.
MAIN PUBLICATIONS
1. E. V. Malakhova , A. D.Malakhov, S. V. Kuznitsova, V. A. Korshun, Yu. A. Berlin, O. P. Varnavskii, A. P. Kadutskii, D. T.Kozhich. “Reagents for Introducing a Fluorescent Deoxyuridine 2-Phenylbenzoxazole Derivative into Oligonucleotides”. Russian Journal of Bioorganic Chemistry 1998, 24 (9), 694–695.
2. E. A. Dikusar, A. P. Kadutskii, N. G. Kozlov, A. P. Yuvchenko and L. A. Mel’nichuk. “Salts of spiro-derivatives of benzo[f]quinoline and several natural carboxylic acids”. Chemistry of Natural Compounds 2006, 42 (1), 118–120. (Abstract)
3. A. P. Kadutskii and N. G. Kozlov. “One-stage synthesis of benzoacridine and benzophenanthroline functionalized derivatives”. Russian Journal of Organic Chemistry 2006, 42 (5), 748–751. (Abstract)
3. A. P. Kadutskii and N. G. Kozlov. “Synthesis of spirocyclic benzo[f]quinoline derivatives by cascade heterocyclization of dimedone, 2-naphthylamine, and formaldehyde”. Russian Journal of Organic Chemistry 2006, 42 (6), 855–859. (Abstract)
4. A. P. Kadutskii, N. G. Kozlov and S. L. Bondarev. “Crotonization in the benzo[a]acridine series. Synthesis of naphtho[2,1-j][1,7]phenanthroline derivatives”. Russian Journal of Organic Chemistry 2006, 42 (9), 1383–1387. (Abstract)
5. A. P. Kadutskii and N. G. Kozlov. “Reaction of 6-aminoquinoline with formaldehyde and cyclic β-diketones. Synthesis of benzo[b]- and indeno[2,1-b][4,7]-phenanthroline derivatives”. Russian Journal of Organic Chemistry 2006, 42 (9), 1388–1391. (Abstract)
6. A. P. Kadutskii, N. G. Kozlov. “A Novel Three-Component Reaction of Anilines, Formaldehyde and β-Diketones: Simple Synthesis of 3-Spirosubstituted 1,2,3,4-Tetrahydroquinolines”. Synlett 2006, 19, 3349–3351. (Abstract)
7. N. G. Kozlov, E. V. Koroleva, Zh. V. Ignatovich, K. N. Gusak and A. P. Kadutskii. “Condensation of quinolin-6-amine with 5-(p-methoxyphenyl)-cyclohexane-1,3-dione and substituted benzaldehydes”. Russian Journal of Organic Chemistry 2007, 43 (6), 901–906. (Abstract)
8. N. G. Kozlov and A. P. Kadutskii. “A novel three-component reaction of anilines, formaldehyde and dimedone: simple synthesis of spirosubstituted piperidines”. Tetrahedron Letters, 2008, 49 (29), 4560–4562. (Abstract)
9. N. G. Kozlov, S. L. Bondarev, A. P. Kadutskii, L. I. Basalaeva and F. S. Pashkovskii. “Tetronic acid in reaction with aromatic aldehydes and 2-naphthylamine. Investigation of fluorescent and nonlinear-optical characteristics of compounds obtained”. Russian Journal of Organic Chemistry 2008, 44 (7), 1031–1037. (Abstract)
10. E. A. Dikusar, V. I. Potkin, N. G. Kozlov, A. P. Kadutskii and A. P. Yuvchenko, et al. “Synthesis of 1,3- and 1,4-bis-methoxy- and ethoxy-4-(m-carborane-C-methanoyloxy)phenylmethylene- and phenylmethyl]phenylenediamines”. Russian Journal of General Chemistry 2008, 78 (11), 2061–2063. (Abstract)
11. A. P. Kadutskii, N. G. Kozlov and F. S. Pashkovskii. “Synthesis of benzo[f]quinoline derivatives by three-component condensation of tetronic acid with naphthalen-2-amine and formaldehyde”. Russian Journal of Organic Chemistry 2009, 45 (3), 399–403. (Abstract)
12. E. A. Dikusar, V. I. Potkin, N. G. Kozlov and A. P. Kadutskii. “Preparative synthesis of 3- and 4-(3-alkoxy-4-acyloxyphenylmethylamino)benzoic acids”. Russian Journal of Organic Chemistry 2009, 45 (6), 853–857. (Abstract)
13. Zh. V. Ignatovich, A. P. Kadutskii, E. V. Koroleva, A. V. Baranovskii and K. N. Gusak. “Reductive transformations of Schiff bases in the synthesis of functionally substituted heteroaromatic amines”. Russian Journal of Organic Chemistry 2009, 45 (7), 1070–1078. (Abstract)
14. N. G. Kozlov, S. L. Bondarev, A. P. Kadutskii and L. I. Basalaeva. “Synthesis of methyl 12-aryl-9,9-dimethyl-11-oxo-7,8,9,10,11,12-hexahydrobenzo[a]acridine-10-carboxylate”. Russian Journal of Organic Chemistry 2010, 46 (2), 202–208. (Abstract)
15. N. G. Kozlov, K. N. Gusak and A. P. Kadutskii. “Development of the catalytic synthesis of compounds of the quinoline series (the N. S. Kozlov reaction)” (Review). Chemistry of Heterocyclic Compounds 2010, 46 (5), 505–528. (Abstract)
16. A. P. Kadutskii and N. G. Kozlov. “Condensation of N-monosubstituted 2-naphthylamines, formaldehyde, and cyclic β-diketones. One-pot synthesis of 2,4-disubstituted derivatives of 1,2,3,4-tetrahydrobenzo[f]quinoline”. Russian Journal of Organic Chemistry 2010, 46 (9), 1327–1331. (Abstract)
17. A. P. Kadutskii, N. G. Kozlov and Yu. D. Zhikharko. “Heterocyclization of N,N′-disubstituted p-phenylenediamines with cyclich β-diketones and formaldehyde. Synthesis of new pyrido[2,3-g]quinoline derivatives”. Russian Journal of Organic Chemistry 2011, 47 (3), 412–416. (Abstract)
Research Scientist — Alexander R. Nabiullin
Address: office №312, 13 Surganov street, Minsk 220072, Belarus
Phone / Fax: +375 17 284-20-55
E-mail: nabiullinifoch.bas-net.by
EDUCATION
RESEARCH INTERESTS
HONORS AND AWARDS
MAIN PUBLICATIONS
EDUCATION
Graduated from the Lyceum of Belarusian State University (1996-1998).
BSc degree in Chemistry (1998 to 2003, Belarusian State University).
Worked as a research assistant at the department of organic chemistry (2003).
Working as engineer and a research assistant at the Institute of Physical Organic Chemistry (since 2004).
Working as a school teacher since 1998.
During 2009-2012 was a postgraduate student. Project title: "Modification of polymer fiber and nanoparticles for biomolecule immobilization".
RESEARCH INTERESTS
Methods of protein extraction and purification, organic, inorganic, polymer and colloidal chemistry, biochemistry, nanotechnology, chemical technology, veterinary drugs.
HONORS AND AWARDS
Winner of Olympiad in chemistry Innocentive-2003 (MSU, Moscow).
Winner of International Olympiad in nanotechnology (2007-2009) (MSU, Moscow).
MAIN PUBLICATIONS
1. Nabiullin A. R., Shmanai V. V. "Functionalization of polyester fiber with aldehyde groups for protein immobilization". Proceedings of the National Academy of Sciences of Belarus, Series of chemical sciences 2009, 3, 101–104. — In Russian.
2. Nabiullin A. R., Shmanai V. V. "Functionalization of poly-ε-capramide fiber with aldehyde groups for protein immobilization". Proceedings of the National Academy of Sciences of Belarus, Series of chemical sciences 2010, 3, 88–91. — In Russian.
Research Scientist — Dzmitry V. Tsaulouski
Address: office №313, 13 Surganov street, Minsk 220072, Belarus
Phone / Fax: +375 17 284-20-55
EDUCATION
RESEARCH INTERESTS
MAIN PUBLICATIONS
EDUCATION
1990 – 1995 Belarusian State University, Chemistry Department
2009 – 2013 Ph. D. Student at the Institute of Bioorganic Chemistry
RESEARCH INTERESTS
Pure organic synthesis, scaling laboratory protocols.
MAIN PUBLICATIONS
1. Khripach V. A., Zhabinskii V. N., Tsavlovskii D. V. "Synthesis of fatty acyl derivatives of 24-epibrassinolide". The Journal of Steroid Biochemistry and Molecular Biology 2013, 137, 345–354. (Abstract)
2. Khripach V. A., Zhabinskii V. N., Zhiburtovich Y. Y., Ivanova G. V., Konstantinova O. V., Tsavlovskii D. V., Lorenz S., Schneider B. "Preparation and synthetic application of partially protected brassinosteroids". Steroids 2010, 75 (1), 27–33. (Abstract)
3. Khripach V. A., Zhabinskii V. N., Tsavlovskii D. N., Drachenova O. A., Ivanova G. V., Konstantinova O. V., Zavadskaya M. I., Lyakhova A. S., Govorova A. A, Groen M. B., de Groot A. "Synthesis of C-5′-alkyl substituted 17-spirofuran 19-norsteroids". Steroids 2001, 60 (7), 569–579. (Abstract)
Junior Research Scientist — Yauhen A. Kuzmitovich
Address: office №312, 13 Surganov street, Minsk 220072, Belarus
Phone / Fax: +375 17 284-20-55
E-mail: kuzmitovichtut.by
EDUCATION
RESEARCH INTERESTS
MAIN PUBLICATIONS
EDUCATION
2006 – 2011 Belarusian State University, Department of Chemistry.
RESEARCH INTERESTS
MAIN PUBLICATIONS
Junior Research Scientist — Dmitry A. Tsybulsky
Address: office №311, 13 Surganov street, Minsk 220072, Belarus
Phone / Fax: +375 17 284-20-55
E-mail: tsybulskiyandex.ru
EDUCATION
RESEARCH INTERESTS
MAIN PUBLICATIONS
EDUCATION
Chemistry department of BSU, 2008.
RESEARCH INTERESTS
Fluorescent dyes, modified controlled pore glass.
Current activity: research on the luminescence properties of the fluorescein dyes on oligonucleotides, depending on the linker structure and oligonucleotide sequence.
MAIN PUBLICATIONS
1. Kvach M. V., Tsybulsky D. A., Shmanai V. V., Prokhorenko I. A., Stepanova I. A., Korshun V. A. "Non-nucleoside phosphoramidites of xanthene dyes (FAM, JOE, and TAMRA) for oligonucleotide labeling". Current Protocols in Nucleic Acid Chemistry 2013, Suppl. 52, 4.55.1–4.55.33. (Abstract)
2. Ryazantsev D. Y., Tsybulsky D. A., Prokhorenko I. A., Kvach M. V., Martynenko Y. V., Philipchenko P. M., Shmanai V. V., Korshun V. A., Zavriev S. K. "Two-dye and one- or two-quencher DNA probes for real-time PCR assay: synthesis and comparison with a TaqMan™ probe". Analytical and Bioanalytical Chemistry 2012, 404, 59–68. (Abstract)
3. Tsybulsky D. A., Kvach M. V., Stepanova I. A., Korshun V. A., Shmanai V. V. "4′,5′-Dichloro-2′,7′-dimethoxy-5(6)-carboxyfluorescein (JOE): synthesis and spectral properties of oligonucleotide conjugates". The Journal of Organic Chemistry 2012, 77, 977–984. (Abstract)
Junior Research Scientist — Natalia V. Pilchenko
Address: office №210, 13 Surganov street, Minsk 220072, Belarus
Phone / Fax: +375 17 292-26-35
E-mail: n.pilchenkomail.ru
EDUCATION
RESEARCH INTERESTS
MAIN PUBLICATIONS
EDUCATION
RESEARCH INTERESTS
MAIN PUBLICATIONS
Junior Research Scientist — Aliaksandr S. Kruhlik
Address: office №313, 13 Surganov street, Minsk 220072, Belarus
Phone / Fax: +375 17 284-20-55
E-mail: a.kruhlikgmail.com
EDUCATION
BSc degree in Chemistry (2007 to 2012, Belarusian State University).
RESEARCH INTERESTS
Synthesis of reagents for immunoassay of antibiotics.
Junior Research Scientist — Egor A. Ulaschick
Address: office №227, 13 Surganov street, Minsk 220072, Belarus
Phone / Fax: +375 17 284-20-55
E-mail: ulaschickgmail.com
EDUCATION
RESEARCH INTERESTS
MAIN PUBLICATIONS
EDUCATION
Belarusian State University, B.S. in Chemistry (2013)
Lyceum of Belarusian State University (2008)
RESEARCH INTERESTS
Total organic synthesis, labeling of biomolecules, fluorescent dyes, nucleoside synthesis.
MAIN PUBLICATIONS
1. Astashko D. A., Ulashchik E. A., Tyvorskii V. I. "Synthesis of (±)-bicolorin, the aggregation pheromone of beech bark beetle Taphrorychus bicolor". Russian Journal of Organic Chemistry 2013, 49 (12), 1803–1806. (Abstract)
Ph.D. Student — Sergey N. Tumanov
Address: office №313, 13 Surganov street, Minsk 220072, Belarus
Phone / Fax: +09-3737599 x89827
E-mail: tumanovphdgmail.com
EDUCATION
RESEARCH INTERESTS
MAIN PUBLICATIONS
EDUCATION
RESEARCH INTERESTS
MAIN PUBLICATIONS
Ph.D. Student — Maksim Yu. Tatulchenkov
Address: office №311, 13 Surganov street, Minsk 220072, Belarus
Phone / Fax: +375 17 284-20-55
E-mail: tatulmaxmail.ru
EDUCATION
RESEARCH INTERESTS
HONORS AND AWARDS
EDUCATION
BSc degree in Chemistry (2007 to 2011, Belarusian State University).
MSc degree in Chemistry (2011 to 2012, Institute of Physical Organic Chemistry NASB).
RESEARCH INTERESTS
Synthesis of reagents for bioconjugation of nanoparticles, investigation of the properties of the conjugates, synthesis of amidophosphite (phosphoramidite) reagents and solid supports for the synthesis of modified oligonucleotides.
Current activity: modification of thioctic (lipoic) acid for conjugation purposes, synthesis of gold nanoparticles conjugated with oligonucleotides; modification of AFM cantilevers for single molecule force measurements.
HONORS AND AWARDS
Diplomas of the 4th (2010) and the 5th (2011) All-Russian with international participation Olympiad in nanotechnologies: "Nanotechnologies - breakthrough to the future", nanochemistry section.
Ph.D. Student — Maksim A. Fomich
Address: office №313, 13 Surganov street, Minsk 220072, Belarus
Phone / Fax: +375 17 284-20-55
E-mail: mfomichgmail.com
EDUCATION
RESEARCH INTERESTS
MAIN PUBLICATIONS
EDUCATION
|
2013 – present |
Ph.D. Student at the Laboratory of Bioconjugate Chemistry, |
|
2012 – 2013 |
M.Sc. Student at the National Academy of Sciences of Belarus. |
|
2007 – 2012 |
Student at Belarusian State University, Chemistry Department. Specialization: organic chemistry. |
RESEARCH INTERESTS
Isotope-modified polyunsaturated fatty acids and their derivatives, click chemistry reagents, bioconjugation methods.
MAIN PUBLICATIONS
M.Sc. Student — Yury V. Martynenko
Address: office №311, 13 Surganov street, Minsk 220072, Belarus
Phone / Fax: +375 17 284-20-55
E-mail: yrmartgmail.com
EDUCATION
RESEARCH INTERESTS
MAIN PUBLICATIONS
EDUCATION
2013 – present M. Sc. Student at the National Academy of Sciences of Belarus. Supervisor: Dr. V. V. Shmanai.
2008 – 2013 Student at Belarusian State University, Chemistry Department. specialization: organic chemistry.
Diploma Thesis: "Synthesis of branching reagents for modification of DNA probes with fluorescent dyes and quenchers". Supervisor: Dr. V. V. Shmanai.
2004 – 2008 Gymnasium 29, Minsk.
RESEARCH INTERESTS
Organic synthesis of branching reagents (doublers, treblers) for modification of biomolecules (oligonucleotides, proteins).
MAIN PUBLICATIONS
1. Nabiullin A. R.,Ulaschick E. A., Matynenko Y. V., Shmanai V. V. "Obtaining of stabilized monodisperse magnetic nanoparticles for biotechnologies applications". Abstracts for the Conference of polymer composites and tribology 2009.
2. Bekish A. V., Lysenko I. L., Martynenko Yu. V., Kuzmitovich Ya. A. "A study of the carbon skeleton degradation during oxidation of the primary alcohols in the synthesis of the the deuterated polyunsaturated fatty acids". Abstracts for the Conference of Biological Active Substances 2011.
3. Dmitry Y. Ryazantsev, Dmitry A. Tsybulsky, Igor A. Prokhorenko, Maksim V. Kvach and Yury V. Martynenko, et al. "Two-dye and one- or two-quencher DNA probes for real-time PCR assay: synthesis and comparison with a TaqMan™ probe". Analytical and Bioanalytical Chemistry 2012, 404 (1), 59–68.
Page last updated: 01.31.2014 10:13